30 May Brand new placentas away from ladies infected which have T
Straight sign regarding T. cruzi can't be eliminated, tinychat seznamka however with very early detection and you may procedures it could be healed with 100% achievement . During congenital T. cruzi disease, this new parasite are at the brand new fetus because of the crossing the placental barrier. cruzi showcase really serious alterations in the ECM. This effect provides evidence that the parasite triggers reorganization of your ECM in a fashion that controls this new inflammatory and you may resistant answers of server. Within this framework, this new parasite load additionally the immunological condition out of both mom and you will fetus, hence dictate the likelihood of congenital transmission out-of T. cruzi, is determinants on the disease . Throughout the infective process, collagen, heparan sulfate, and you will laminin was destroyed by parasite, however, interestingly, fibronectin is not inspired, so that the selective depletion of your ECM might possibly be part of the latest invasion process .
T. cruzi is also transmitted owing to bloodstream transfusion, organ transplantation, consumption regarding polluted food otherwise liquids, and you will congenital otherwise sexual alert
During the webpages off number 1 problems, the new metacyclic trypomastigotes infect local macrophages, fibroblasts, and you may mesenchymal architecture, however the illness out of faraway frameworks after dissemination from bloodstream boats are unfamiliar.